{
  "markdown": "# Roots by Benda — Pharmaceutical & Bioequivalence Intelligence MCP Server\n\n[![smithery badge](https://smithery.ai/badge/twohalves/pharma-regulatory)](https://smithery.ai/servers/twohalves/pharma-regulatory)\n\n**Drug safety, interactions, adverse events, and regulatory data in one MCP.** Check any drug or active ingredient against DrugBank, WHO Essential Medicines, FDA FAERS adverse events, drug-drug interactions, Australian TGA ARTG, FDA NDI notifications, and ChEMBL bioactivity — all source-linked and free.\n\nEquivalent data through commercial platforms (Lexicomp, Micromedex, DrugBank Pro) costs $20,000+/year. This MCP is free.\n\n**Live endpoint:** `https://pharma-mcp-server.rootsbybenda.workers.dev/mcp`\n**SSE fallback:** `https://pharma-mcp-server.rootsbybenda.workers.dev/sse`\n\n## Tools\n\n### `check_drug`\nLook up a drug, medicine, active ingredient, or CAS number across DrugBank, WHO Essential Medicines, Australian TGA ARTG, and FDA NDI notifications. Returns identifiers, targets, schedules, dosage forms, indications, and regulatory records.\n\n```\nquery: \"ibuprofen\"\n→ DrugBank: Ibuprofen (DB01050), CAS 15687-27-1, approved/investigational\n  Targets: Prostaglandin G/H synthase 1 & 2, PPAR-gamma, CFTR\n  Drug-Drug Interactions: 100\n  WHO Essential: Yes — ATC M01AE01, analgesic/anti-inflammatory\n  Formulations: IV 5 mg/mL; Oral 200/400/600 mg tablet; Liquid 100-200 mg/5 mL\n  Dosage: 200-400 mg q6-8h; max 1200-2400 mg/day\n  Contraindications: Active GI bleeding; severe renal impairment; third trimester pregnancy\n  TGA ARTG: 10 registered products (BRUFEN 400mg, CALDOLOR IV, NUROFEN PLUS, etc.)\n```\n\n### `check_drug_interactions`\nCheck drug-drug interactions for one drug or a specific pair. Returns interaction severity, mechanism, clinical effect, evidence level, and management recommendations for medication safety review.\n\n```\nquery: \"warfarin aspirin\"\n→ Severity: MAJOR; Mechanism: additive anticoagulant + antiplatelet effect;\n  Clinical: increased bleeding risk; Management: avoid combination or monitor INR closely\n```\n\n### `check_adverse_events`\nCheck FDA FAERS adverse-event records for a drug or active ingredient. Returns total reports, serious outcomes, death reports, top adverse reactions, and common patient age groups.\n\n```\nquery: \"isotretinoin\"\n→ Total reports: 12,847; Serious: 8,231; Deaths: 89; Top reactions: depression,\n  inflammatory bowel disease, suicide attempt; Peak age: 15-25\n```\n\n### `search_pharma`\nSearch across pharmaceutical regulatory and safety databases by keyword. Use for broad discovery across DrugBank, WHO Essential Medicines, TGA ARTG, FAERS, FDA NDI, drug interactions, and ChEMBL bioactivity.\n\n```\nquery: \"SSRI pregnancy\" → matches across FAERS (birth defects), interactions, DrugBank warnings\n```\n\n## Data\n\n| Dataset | Records |\n|---------|---------|\n| Australian TGA ARTG registered medicines | 23,259 |\n| ChEMBL bioactivity records | 7,941 |\n| DrugBank compounds | 4,947 |\n| Drug-drug interactions | 5,000 |\n| FDA FAERS adverse-event records | 2,000 |\n| FDA NDI notifications | 1,330 |\n| WHO Essential Medicines | 782 |\n\n**100% source-traceability:** every record links to DrugBank, WHO, TGA, FDA FAERS, or ChEMBL primary sources.\n\n**Sources:** DrugBank (open data), WHO Model List of Essential Medicines, Australian TGA ARTG, FDA FAERS (Adverse Event Reporting System), FDA New Dietary Ingredient notifications, ChEMBL (EMBL-EBI).\n\n## Quick Start\n\n### Claude Desktop / Claude Code\nAdd to your MCP config:\n```json\n{\n  \"mcpServers\": {\n    \"roots-pharma-regulatory\": {\n      \"url\": \"https://pharma-mcp-server.rootsbybenda.workers.dev/sse\"\n    }\n  }\n}\n```\n\n### Cursor / Windsurf / Zed\nUse the Streamable HTTP endpoint:\n```\nhttps://pharma-mcp-server.rootsbybenda.workers.dev/mcp\n```\n\n## Rate Limits\n\nEvery caller receives full data; a 60 requests/minute abuse-prevention limit applies per IP.\n\n## Built With\n\n- [Cloudflare Workers](https://workers.cloudflare.com/) + [Agents SDK](https://developers.cloudflare.com/agents/)\n- [Cloudflare D1](https://developers.cloudflare.com/d1/) (SQLite at the edge)\n- [Durable Objects](https://developers.cloudflare.com/durable-objects/) (session-scoped rate limiting)\n- [Model Context Protocol](https://modelcontextprotocol.io/) (MCP)\n\n## Who Built This\n\n**Roots by Benda** — regulatory intelligence platform built by Shahar Ben-David with Claude. Pharmaceutical database assembled from primary sources across DrugBank, WHO, TGA, FDA, and ChEMBL.\n\n- Website: [rootsbybenda.com](https://rootsbybenda.com)\n- LinkedIn: [Shahar Ben-David](https://www.linkedin.com/in/shahar-ben-david-25549a3a8/)\n\n## License\n\nMIT\n",
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}